SYNACTIF

THE SCIENCE

THE EVOLUTION OF LYMPHATIC RESEARCH

2003

Collaborative research on the correlation between lymphatic capillaries and skin with the Cutaneous Biology Research Center*
*Cutaneous Biology Research Center (CBRC): Established by Harvard Medical University and Massachusetts General Hospital in 1989 with the support of Shiseido, CBRC is a comprehensive research center for advanced research and development in the field of dermatology.

2006

Discovered that functional deterioration of lymphatic capillaries links to the causes of skin aging

2008

Discovered that lymphatic functions deteriorate due to UV rays

2014

Discovered that lymphatic capillaries degenerate** and impurities leak due to UV rays and aging Inductive factors which play a role in collecting inflammatory factors decrease due to aging
**Degeneration: shrinking of lymphatic capillariesdue to damage caused by UV rays.

2017

Developed unique technology to observe lymphatic capillaries in three dimensions Discovered lymphatic capillaries are lost partly due to aging

LYMPHATIC CAPILLARIES

Key to Promoting Skin Purification and Regeneration

A diagram from Synactif’s research comparing lymphatic capillaries. This shows a damaged capillary with impaired structure due to poorly functioning TGF-beta, illustrating that this is the key to promoting skin purification and regeneration.
A diagram of a healthy, intact lymphatic capillary supported by TGF-beta, based on Synactif’s research, illustrating that this is the key to promoting skin purification and regeneration.

THE APPROACH: PURIFYING BEAUTIFIER

Prevents the Loss of Lymphatic Capillaries Due to Aging

MULBERRY WHITE BARK
LAMIUM ALBUM LEAF
CINNAMOMUM CASSIA BARK

THE ROLE OF PURIFICATION IN SKIN'S REGENERATION FUNCTION

Skin that has higher purification and regeneration abilities preserves a larger number of epidermal stem cells.
Therefore, a large number of these cells means a higher ability to generate new epidermal cells.

Illustration of a cross-sectional diagram of the skin layers (epidermis, dermis, subcutaneous tissue) showing the location of epidermal stem cells and impurities accumulated near the epidermis.
Skin with deteriorated ability to purify and regenerate Itself
Illustration of a cross-sectional diagram of the skin layers (epidermis, dermis, subcutaneous tissue) indicating the location of epidermal stem cells with no accumulation of impurities near the epidermis.
Skin with higher ability to purify and regenerate Itself